Fioricet Storage and Fioricet Interactions

Fioricet Storage

  • Keep out of the reach of children since overdose is especially dangerous in children.
  • Store away from heat and direct light.
  • Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
  • Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

How do I take Fioricet?

Fioricet should be taken exactly as prescribed by your physician. Do not take it in larger amounts or for longer than recommended. Follow the directions on your fioricet prescription label and tell your physician if the medicine seems to stop working as well in relieving your pain.  If Fioricet upsets your stomach take it with food or milk. An overdose of acetaminophen can cause serious harm and damage to your liver. The maximum amount of acetaminophen for an adult is 1 gram per dose and 4 grams per day. Taking more acetaminophen could cause damage to your liver.

Fioricet Interactions with other prescriptions

Fioricet Interaction with other drugs
Fioricet Interaction with other drugs

Taking this medicine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking Fioricet with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Other drugs may interact with acetaminophen, butalbital, and caffeine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

    • Riociguat

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

      • Alfentanil
      • Alprazolam
      • Amobarbital
      • Anisindione
      • Aprobarbital
      • Butabarbital
      • Carisoprodol
      • Chloral Hydrate
      • Chlordiazepoxide
      • Chlorzoxazone
      • Clarithromycin
      • Clonazepam
      • Clorazepate
      • Dantrolene
      • Darunavir
      • Diazepam
      • Dicumarol
      • Doxorubicin
      • Doxorubicin Hydrochloride Liposome
      • Esketamine
      • Estazolam
      • Ethchlorvynol
      • Etonogestrel
      • Flunitrazepam
      • Flurazepam
      • Halazepam
      • Imatinib
      • Iobenguane I 131
      • Isoniazid
      • Ketazolam
      • Lorazepam
      • Lormetazepam
      • Medazepam
      • Mephenesin
      • Mephobarbital
      • Meprobamate
      • Metaxalone
      • Methocarbamol
      • Methohexital
      • Midazolam
      • Nifedipine
      • Nitrazepam
      • Oxazepam
      • Peginterferon Alfa-2b
      • Pentobarbital
      • Phenindione
      • Phenobarbital
      • Phenprocoumon
      • Piperaquine
      • Pixantrone
      • Pneumococcal 13-Valent Vaccine, Diphtheria Conjugate
      • Prazepam
      • Primidone
      • Quazepam
      • Secobarbital
      • Sodium Oxybate
      • Temazepam
      • Thiopental
      • Trazodone
      • Triazolam
      • Ulipristal

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

      • Acenocoumarol
      • Cannabis
      • Carbamazepine
      • Fosphenytoin
      • Lixisenatide
      • Ospemifene
      • Phenytoin
      • Prednisone
      • Warfarin
      • Zidovudine

Fioricet Drug Interaction

Fioricet contains Butalbital, Acetaminophen, and caffeine.  A lot of other pain relievers contain Butalbital, Acetaminophen, and caffeine too.

I can only list some common over the counter medicines that contain Acetaminophen:  Actifed, Alka-Seltzer, Plus Liquid Gels, Anacin, Cepacol, Contac, Coricidin, Dayquil, Dimetapp, Dristan, Excedrin, Feverall …

Some prescriptions that contain acetaminophen are: Ultrace, Fioricet, Oxycodone, Endocet, Tylox …


You also must know what drugs contain Butalbital:  Bupap, Phrenilin, Tencon, Cephadyn; Fioricet, Esgic, Esgic-Plus; Fioricet with Codeine, Floricet with Codeine, Phrenilin with Caffeine and Codeine; Axotal; Fiorinal, Butalbital Compound, Farbital, Idenal; Fiorinal with Codeine, Fiorinal with Codeine III, Ascomp with Codeine, Fiortal with Codeine.

When you take more than one pain killer, you must read very carefully about their components.  Never exceed the max dosage of acetaminophen and butalbital of all the medicines you are taking.   Normally All the packages sent to you have the drug introduction and doctor names and phone number.  Read the drug introduction very carefully and never share the medicines with your sisters, your brothers,  your parents, or any friends. Always do not let the children touch the medicines.

Please donot drink any alcohol (Ethanol) with your Fioricet Because Ethanol together with acetaminophen will cause serious side effects that affect your liver, and Ethanol together with Butalbital will cause side effects of dizziness, drowsiness.

The effects of one or more of the drugs in Fioricet may enhance the effects of other drugs. These may include:

  • Monoamine oxidase inhibitors (MAOIs), antidepressants including Marplan (isocarboxazid), Nardil (phenelzine), and others
  • Tranquilizers such as chlordiazepoxide (Librium)
  • Sedative-hypnotics, such as prescription sleeping pills
  • General anesthesia drugs

Remember to always tell your doctor about any prescription, non-prescription, over-the-counter (OTC), illegal and recreational drugs, herbal remedies, nutritional and dietary supplements, and all other drugs and treatments you’re taking.

Please don’t take herb while you are taking Fioricet. Even Vitamins will have some interaction with Fioricet.

Be honest to place the current medicines you are taking in the health questionnaire  form. The doctor will check whether you are OK to take Fioricet.  If they think your current drugs or herbs have some interaction with Fioricet, they will phone you to discuss the situation with you. So please always leave us the correct phone number. We will never call you to promote you anything.